New advances in the understanding of the role of steroids and steroid receptors in disease.
نویسندگان
چکیده
Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However, dietary consumption of non-steroidal weak oestrogens, such as the soy isoflavone phytoestrogens genistein and diadzein, is associated with a decreased breast cancer risk. This may arise in part from the suboptimal configuration induced in the transactivation helix of oestrogen receptor-beta.
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 29 Pt 2 شماره
صفحات -
تاریخ انتشار 2001